Structure and dissolution of L-leucine-coated salbutamol sulphate aerosol particles.

ABSTRACT: L-Leucine formed different crystalline coatings on salbutamol sulphate aerosol particles depending on the saturation conditions of L-leucine. The work emphasizes a careful characterization of powders where structural compartments such as crystal size and particle coating may affect the performance of drug when administered. The sublimation of L-leucine from the aerosol particles took place 90°C lower temperature than the bulk L-leucine which was attributed to result from the sublimation of L-leucine from nano-sized crystalline domains. The dissolution slowed down and initial dissolution rate decreased with increasing L-leucine content. Decreasing crystalline domains to nano-scale improve heat and mass transfer which was observed as the lowered decomposition temperature of the drug salbutam

SUBMITTER: Raula J 

PROVIDER: S-EPMC3364384 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature