Ontology highlight
ABSTRACT:
SUBMITTER: Cruz-Migoni A
PROVIDER: S-EPMC3364511 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20111101 6057
The structure of BPSL1549, a protein of unknown function from Burkholderia pseudomallei, reveals a similarity to Escherichia coli cytotoxic necrotizing factor 1. We found that BPSL1549 acted as a potent cytotoxin against eukaryotic cells and was lethal when administered to mice. Expression levels of bpsl1549 correlate with conditions expected to promote or suppress pathogenicity. BPSL1549 promotes deamidation of glutamine-339 of the translation initiation factor eIF4A, abolishing its helicase ac ...[more]