Regulatory effect of heat shock protein 70 in stress-induced rat intestinal epithelial barrier dysfunction.

ABSTRACT:

Background

Psychological stress is one of the factors associated with many human diseases; the mechanisms need to be further understood.

Methods

Rats were subjected to chronic water avoid stress. Intestinal epithelial heat shock protein (HSP) 70 was evaluated. The intestinal epithelial permeability was examined with Ussing chamber technique.

Results

HSP70 was detected in normal intestinal epithelial cells. Psychological stress decreased HSP70 in the intestinal epithelial cells that correlated with the stress-induced intestinal epithelial hyperpermeability. Pretreatment with HSP70 abrogated stress-induced intestinal barrier dysfunction.

Conclusions

Chronic stress inhibits HSP70 activity in rat intestinal epithelial layer that is associated with intestinal epithe

SUBMITTER: Yang PC 

PROVIDER: S-EPMC3364627 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature