A new variant of endemic pemphigus foliaceus in El-Bagre, Colombia: the Hardy-Weinberg-Castle law and linked short tandem repeats.

ABSTRACT:

Background

We reported a new variant of endemic pemphigus foliaceus in El Bagre, Colombia.

Aims

Our study performed Complex Segregation Analysis (CSA) and short tandem repeats to discriminate between environmental and/or genetic factors in this disorder.

Materials and methods

The CSA analysis was carried out according to the unified model, implemented using the transmission probabilities implemented in the computer program POINTER, and evaluated by using a software package for population genetic data analysis (GDA), Arlequin. We performed pedigree analyses by using Cyrillic 2.1 software, with a total of 30 families with 50 probands (47 males and 3 females) tested. In parallel to the CSA, we tested for the presence of short tandem repeats from HLA class II, DQ alpha 1,

SUBMITTER: Abreu-Velez AM 

PROVIDER: S-EPMC3364661 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature