Effect of misclassification of antiretroviral treatment status on the prevalence of transmitted HIV-1 drug resistance.

ABSTRACT:

Background

Estimates of the prevalence of transmitted HIV drug resistance (TDR) in a population are derived from resistance tests performed on samples from patients thought to be naïve to antiretroviral treatment (ART). Much of the debate over reliability of estimates of the prevalence of TDR has focused on whether the sample population is representative. However estimates of the prevalence of TDR will also be distorted if some ART-experienced patients are misclassified as ART-naïve.

Methods

The impact of misclassification bias on the rate of TDR was examined. We developed methods to obtain adjusted estimates of the prevalence of TDR for different misclassification rates, and conducted sensitivity analyses of trends in the prevalence of TDR over time using data from the UK H

SUBMITTER: Castro H 

PROVIDER: S-EPMC3364874 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature