TPH2 gene polymorphisms and major depression--a meta-analysis.

ABSTRACT:

Background

Tryptophan hydroxylase-2 (TPH2) is the rate-limiting enzyme in the synthetic pathway for brain serotonin and is considered key factor for maintaining normal serotonin transmission in the central neuron system (CNS). Gene-disease association studies have reported a relationship between TPH2 and major depressive disorder (MDD) in different populations, however subsequent studies have produced contradictory results.

Objectives

We performed a systematic overview and a meta-analysis with all available data up-to-date.

Methods

We scrutinized PubMed, Embase, HuGNet and China National Knowledge Infrastructure (CNKI ) and last update was held on October 2011. We also searched the manuscripts and the supplementary documents of the published genome-wide association st

SUBMITTER: Gao J 

PROVIDER: S-EPMC3365065 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature