Multiple histone methyl and acetyltransferase complex components bind the HLA-DRA gene.

ABSTRACT: Major histocompatibility complex class II (MHC-II) genes are fundamental components that contribute to adaptive immune responses. While characterization of the chromatin features at the core promoter region of these genes has been studied, the scope of histone modifications and the modifying factors responsible for activation of these genes are less well defined. Using the MHC-II gene HLA-DRA as a model, the extent and distribution of major histone modifications associated with active expression were defined in interferon-γ induced epithelial cells, B cells, and B-cell mutants for MHC-II expression. With active transcription, nucleosome density around the proximal regulatory region was diminished and histone acetylation and methylation modifications were distributed throughout the gene in

SUBMITTER: Choi NM 

PROVIDER: S-EPMC3365104 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature