Exercise increases serum fibroblast growth factor 21 (FGF21) levels.

ABSTRACT: Fibroblast growth factor 21 (FGF21) increases glucose uptake. It is unknown if FGF21 serum levels are affected by exercise.This was a comparative longitudinal study. Anthropometric and biochemical evaluation were carried out before and after a bout of exercise and repeated after two weeks of daily supervised exercise. The study sample was composed of 60 sedentary young healthy women. The mean age was 24±3.7 years old, and the mean BMI was 21.4±7.0 kg/m². The anthropometric characteristics did not change after two weeks of exercise. FGF21 levels significantly increased after two weeks of exercise (276.8 ng/l (142.8-568.6) vs. (460.8 (298.2-742.1), p<0.0001)). The delta (final-basal) log of serum FGF21, adjusted for BMI, showed a significant positive correlation with basal glucose (r?=?0.23, p?=?0.04), mean maximal heart rate (MHR) (r?=?0.54, p<0.0001), mean METs (r?=?0.40, p?=?0.002), delta plasma epinephrine (r?=?0.53, p<0.0001) and delta plasma FFAs (r?=?0.35, p?=?0.006). A stepwise linear regression model showed that glucose, MHR, METs, FFAs, and epinephrine, were factors independently associated with the increment in FGF21 after the exercise program (F?=?4.32; r²?=?0.64, p<0.0001).Serum FGF21 levels significantly increased after two weeks of physical activity. This increment correlated positively with clinical parameters related to the adrenergic and lipolytic response to exercise.ClinicalTrials.gov NCT01512368.

SUBMITTER: Cuevas-Ramos D 

PROVIDER: S-EPMC3365112 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature