Molecular marks for epigenetic identification of developmental and cancer stem cells.

ABSTRACT:

Unlabelled

Epigenetic regulations of genes by reversible methylation of DNA (at the carbon-5 of cytosine) and numerous reversible modifications of histones play important roles in normal physiology and development, and epigenetic deregulations are associated with developmental disorders and various disease states, including cancer. Stem cells have the capacity to self-renew indefinitely. Similar to stem cells, some malignant cells have the capacity to divide indefinitely and are referred to as cancer stem cells. In recent times, direct correlation between epigenetic modifications and reprogramming of stem cell and cancer stem cell is emerging. Major discoveries were made with investigations on reprogramming gene products, also known as master regulators of totipotency and inducer o

SUBMITTER: Patra SK 

PROVIDER: S-EPMC3365374 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature