Total synthesis of piericidin A1. Application of a modified Negishi carboalumination-nickel-catalyzed cross-coupling.

ABSTRACT: A total synthesis of the mitochondrial complex I inhibitor piericidin A1 is described. It features a unique strategy for the key disconnection, highlighting a modified Negishi carboalumination/Ni-catalyzed cross-coupling on a polyenyne precursor.

SUBMITTER: Lipshutz BH 

PROVIDER: S-EPMC3365511 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature