Neurod1 is essential for the survival and maturation of adult-born neurons.

ABSTRACT: The transcriptional program that controls adult neurogenesis is unknown. We generated mice with an inducible stem cell-specific deletion of Neurod1, resulting in substantially fewer newborn neurons in the hippocampus and olfactory bulb. Thus, Neurod1 is cell-intrinsically required for the survival and maturation of adult-born neurons.

SUBMITTER: Gao Z 

PROVIDER: S-EPMC3365543 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature