A bayesian approach to surrogacy assessment using principal stratification in clinical trials.

ABSTRACT: A surrogate marker (S) is a variable that can be measured earlier and often more easily than the true endpoint (T) in a clinical trial. Most previous research has been devoted to developing surrogacy measures to quantify how well S can replace T or examining the use of S in predicting the effect of a treatment (Z). However, the research often requires one to fit models for the distribution of T given S and Z. It is well known that such models do not have causal interpretations because the models condition on a postrandomization variable S. In this article, we directly model the relationship among T, S, and Z using a potential outcomes framework introduced by Frangakis and Rubin (2002, Biometrics 58, 21-29). We propose a Bayesian estimation method to evaluate the causal probabilities associ

SUBMITTER: Li Y 

PROVIDER: S-EPMC3365598 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature