Precore mutation of hepatitis B virus may contribute to hepatocellular carcinoma risk: evidence from an updated meta-analysis.

ABSTRACT:

Background

Studies focused on the correlation of mutations in the genome of Hepatitis B Virus (HBV) like Pre-S mutation, Basal Core promoter (BCP), Enhancer II (EnhII), especially Precore mutation, with the risk of hepatocellular carcinoma (HCC) have triggered stiff controversies. With an increasing number of studies in this field recently, we conducted this meta-analysis to appraise the correlations.

Methods

We searched the commonly used databases both in English and Chinese till February 1(st), 2012. Meta-analysis was performed in fixed/random-effects models using STATA 10.0. Publication bias was examined through Egger's test and Begg's funnel plot.

Results

In total, 85 case-control studies were included involving 16745 HBV-infected patients, of whom 5781 had HCC. S

SUBMITTER: Liao Y 

PROVIDER: S-EPMC3365888 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature