Scaffolding catalysts: highly enantioselective desymmetrization reactions.

ABSTRACT: Ex-changing places: a highly enantioselective desymmetrization of 1,2-diols has been developed in which the catalyst utilizes reversible covalent bonding to the substrate to achieve both high selectivity and rate acceleration (see scheme, PMP=pentalmethylpiperidine, TBS=tert-butyldimethylsilyl). Induced intramolecularity is responsible for the enhanced rate, thus allowing the reaction to be performed at room temperature.

SUBMITTER: Sun X 

PROVIDER: S-EPMC3366164 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature