Coarse-grained simulation of myosin-V movement.

ABSTRACT: We describe the development of a hierarchic modelling method applied to simulating the processive movement of the myosin-V molecular motor protein along an actin filament track. In the hierarchic model, three different levels of protein structure resolution are represented: secondary structure, domain, and protein, with the level of detail changing according to the degree of interaction among the molecules. The integrity of the system is maintained using a tree of spatially organised bounding volumes and distance constraints. Although applied to an actin-myosin system, the hierarchic framework is general enough so that it may easily be adapted to a number of other large biomolecular systems containing in the order of 100 proteins. We compared the simulation results with biophysical data, a

SUBMITTER: Katsimitsoulia Z 

PROVIDER: S-EPMC3366208 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature