Focal therapy for localised unifocal and multifocal prostate cancer: a prospective development study.

ABSTRACT:

Background

Radical whole-gland therapy can lead to significant genitourinary and rectal side-effects for men with localised prostate cancer. We report on whether selective focal ablation of unifocal and multifocal cancer lesions can reduce this treatment burden.

Methods

Men aged 45-80 years were eligible for this prospective development study if they had low-risk to high-risk localised prostate cancer (prostate specific antigen [PSA] ≤15 ng/mL, Gleason score ≤4 + 3, stage ≤T2), with no previous androgen deprivation or treatment for prostate cancer, and who could safely undergo multiparametric MRI and have a general anaesthetic. Patients received focal therapy using high-intensity focused ultrasound, delivered to all known cancer lesions, with a margin of normal tissue, ident

SUBMITTER: Ahmed HU 

PROVIDER: S-EPMC3366323 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature