Association of prostate cancer risk with SNPs in regions containing androgen receptor binding sites captured by ChIP-On-chip analyses.

ABSTRACT:

Background

Genome-wide association studies (GWAS) have identified approximately three dozen single nucleotide polymorphisms (SNPs) consistently associated with prostate cancer (PCa) risk. Despite the reproducibility of these associations, the molecular mechanism for most of these SNPs has not been well elaborated as most lie within non-coding regions of the genome. Androgens play a key role in prostate carcinogenesis. Recently, using ChIP-on-chip technology, 22,447 androgen receptor (AR) binding sites have been mapped throughout the genome, greatly expanding the genomic regions potentially involved in androgen-mediated activity.

Methodology/principal findings

To test the hypothesis that sequence variants in AR binding sites are associated with PCa risk, we performed a system

SUBMITTER: Lu Y 

PROVIDER: S-EPMC3366362 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature