CD19 is a major B cell receptor-independent activator of MYC-driven B-lymphomagenesis.

ABSTRACT: PAX5, a B cell-specific transcription factor, is overexpressed through chromosomal translocations in a subset of B cell lymphomas. Previously, we had shown that activation of immunoreceptor tyrosine-based activation motif (ITAM) proteins and B cell receptor (BCR) signaling by PAX5 contributes to B-lymphomagenesis. However, the effect of PAX5 on other oncogenic transcription factor-controlled pathways is unknown. Using a MYC-induced murine lymphoma model as well as MYC-transformed human B cell lines, we found that PAX5 controls c-MYC protein stability and steady-state levels. This promoter-independent, posttranslational mechanism of c-MYC regulation was independent of ITAM/BCR activity. Instead i

SUBMITTER: Chung EY 

PROVIDER: S-EPMC3366393 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature