SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.

ABSTRACT: Chronic obstructive pulmonary disease/emphysema (COPD/emphysema) is characterized by chronic inflammation and premature lung aging. Anti-aging sirtuin 1 (SIRT1), a NAD+-dependent protein/histone deacetylase, is reduced in lungs of patients with COPD. However, the molecular signals underlying the premature aging in lungs, and whether SIRT1 protects against cellular senescence and various pathophysiological alterations in emphysema, remain unknown. Here, we showed increased cellular senescence in lungs of COPD patients. SIRT1 activation by both genetic overexpression and a selective pharmacological activator, SRT1720, attenuated stress-induced premature cellular senescence and protected against em

SUBMITTER: Yao H 

PROVIDER: S-EPMC3366403 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature