Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells.

ABSTRACT: Malignant progression in cancer requires populations of tumor-initiating cells (TICs) endowed with unlimited self renewal, survival under stress, and establishment of distant metastases. Additionally, the acquisition of invasive properties driven by epithelial-mesenchymal transition (EMT) is critical for the evolution of neoplastic cells into fully metastatic populations. Here, we characterize 2 human cellular models derived from prostate and bladder cancer cell lines to better understand the relationship between TIC and EMT programs in local invasiveness and distant metastasis. The model tumor subpopulations that expressed a strong

SUBMITTER: Celia-Terrassa T 

PROVIDER: S-EPMC3366719 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature