Binding of hepatitis A virus to its cellular receptor 1 inhibits T-regulatory cell functions in humans.

ABSTRACT:

Background & aims

CD4+ T-regulatory (Treg) cells suppress immune responses and control self-tolerance and immunity to pathogens, cancer, and alloantigens. Most pathogens activate Treg cells to minimize immune-mediated tissue damage and prevent clearance, which promotes chronic infections. However, hepatitis A virus (HAV) temporarily inhibits Treg-cell functions. We investigated whether the interaction of HAV with its cellular receptor 1 (HAVCR1), a T-cell co-stimulatory molecule, inhibits the function of Treg cells to control HAV infection.

Methods

We studied the effects of HAV interaction with HAVCR1 on human T cells using binding, signal transduction, apoptosis, activation, suppression, cytokine production, and confocal microscopy analyses. Cytokines were analyzed in sera

SUBMITTER: Manangeeswaran M 

PROVIDER: S-EPMC3367104 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature