TTC7B emerges as a novel risk factor for ischemic stroke through the convergence of several genome-wide approaches.

ABSTRACT: We hereby propose a novel approach to the identification of ischemic stroke (IS) susceptibility genes that involves converging data from several unbiased genetic and genomic tools. We tested the association between IS and genes differentially expressed between cases and controls, then determined which data mapped to previously reported linkage peaks and were nominally associated with stroke in published genome-wide association studies. We first performed gene expression profiling in peripheral blood mononuclear cells of 20 IS cases and 20 controls. Sixteen differentially expressed genes mapped to reported whole-genome linkage peaks, including the TTC7B gene, which has been associated with major cardiovascular disease. At the TTC7B locus, 46 tagging polymorphisms were tested for association

SUBMITTER: Krug T 

PROVIDER: S-EPMC3367223 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature