Hematologic abnormalities associated with simian immunodeficieny virus (SIV) infection mimic those in HIV infection.

ABSTRACT:

Background

Studies of hematologic abnormalities in HIV-infected patients are confounded by a multitude of factors. A retrospective data analysis of simian immunodeficieny virus (SIV)-infected rhesus macaques (RM) of Indian origin was performed to determine the prevalence of hematologic abnormalities free of these confounds.

Methods

Hematologic data from RM inoculated with SIV and without antiviral therapy were examined pre-inoculation, and throughout infection and the development of AIDS.

Results

Anemia, thrombocytopenia, lymphopenia, eosinophilia, and neutropenia all increased in prevalence with SIV infection. Significant increases in prevalence for both neutropenia and neutrophilia were also detected in SIV-infected macaques. SIV-infected macaques also had lower lym

SUBMITTER: Gill AF 

PROVIDER: S-EPMC3367385 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature