Expression of CD82 in human trophoblast and its role in trophoblast invasion.

ABSTRACT:

Background

Well-controlled trophoblast invasion at maternal-fetal interface is a critical event for the normal development of placenta. CD82 is a member of transmembrane 4 superfamily, which showed important role in inhibiting tumor cell invasion and migration. We surmised that CD82 are participates in trophoblast differentiation during placenta development.

Methodology/principal findings

CD82 was found to be strongly expressed in human first trimester placental villous and extravillous trophoblast cells as well as in trophoblast cell lines. To investigate whether CD82 plays a role in trophoblast invasion and migration, we further utilized human villous explants culture model on matrigel and invasion/migration assay of trophoblast cell line HTR8/SVneo. CD82 siRNA significant

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC3367946 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature