Ontology highlight
ABSTRACT:
SUBMITTER: Basseres DS
PROVIDER: S-EPMC3368092 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Basseres Daniela S DS D'Alò Francesco F Yeap Beow Y BY Löwenberg Ester C EC Gonzalez David A DA Yasuda Hiroyuki H Dayaram Tajhal T Kocher Olivier N ON Godleski John J JJ Richards William G WG Meyerson Matthew M Kobayashi Susumu S Tenen Daniel G DG Halmos Balázs B Costa Daniel B DB
Lung cancer (Amsterdam, Netherlands) 20120216 1
<h4>Purpose</h4>We sought to determine the mechanisms of downregulation of the airway transcription factor Foxa2 in lung cancer and the expression status of Foxa2 in non-small-cell lung cancer (NSCLC).<h4>Methods</h4>A series of 25 lung cancer cell lines were evaluated for Foxa2 protein expression, FOXA2 mRNA levels, FOXA2 mutations, FOXA2 copy number changes and for evidence of FOXA2 promoter hypermethylation. In addition, 32 NSCLCs were sequenced for FOXA2 mutations and 173 primary NSCLC tumor ...[more]