Dysregulation of circulating microRNAs and prediction of aggressive prostate cancer.

ABSTRACT:

Background

It is becoming increasingly evident that microRNAs (miRNAs) are associated with the development and progression of prostate cancer (PCa).

Methods

We examined the hypothesis that plasma miRNA levels can differentiate patients by aggressiveness in 82 PCa patients. Taqman based quantitative RT-PCR assays were performed to measure copy number of target miRNAs.

Results

miR-20a was significantly overexpressed in plasma from patients with stage 3 tumors compared to stage 2 or below (P = 0.03). The expression levels for miR-20a and miR-21 were significantly increased in patients with high risk CAPRA scores (16,623 and 1,595 copies, respectively). Significantly increased miR-21 and miR-145 expression were observed for patients with intermediate or high risk D'Amico

SUBMITTER: Shen J 

PROVIDER: S-EPMC3368098 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature