Gram-negative and Gram-positive bacterial infections give rise to a different metabolic response in a mouse model.

ABSTRACT: Metabolomics has become an important tool to study host-pathogen interactions and to discover potential novel therapeutic targets. In an attempt to develop a better understanding of the process of pathogenesis and the associated host response we have used a quantitative (1)H NMR approach to study the metabolic response to different bacterial infections. Here we describe that metabolic changes found in serum of mice that were infected with Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli and Pseudomonas aeruginosa can distinguish between infections caused by Gram-positive and Gram-negative bacterial strains. By combining the results of the mouse study with those of bacterial footprinting culture experiments, bacterially secreted metabolites could be identified as potential

SUBMITTER: Hoerr V 

PROVIDER: S-EPMC3368387 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature