Low-grade inflammation and the phenotypic expression of myocardial fibrosis in hypertrophic cardiomyopathy.

ABSTRACT:

Objective

To investigate the role of inflammation in the phenotypic expression of myocardial fibrosis in hypertrophic cardiomyopathy (HCM).

Design

Clinical study.

Setting

Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland.

Subjects

Twenty-four patients with a single HCM-causing mutation D175N in the α-tropomyosin gene and 17 control subjects.

Main outcome measures

Endomyocardial biopsy samples taken from the patients with HCM were compared with matched myocardial autopsy specimens. Levels of high-sensitivity C-reactive protein (hsCRP) and proinflammatory cytokines were measured in patients and controls. Myocardial late gadolinium enhancement (LGE) in cardiac MRI (CMRI) was detected.

Results

Endomyocardial samples in pati

SUBMITTER: Kuusisto J 

PROVIDER: S-EPMC3368494 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature