Systems analysis of inflammatory bowel disease based on comprehensive gene information.

ABSTRACT:

Background

The rise of systems biology and availability of highly curated gene and molecular information resources has promoted a comprehensive approach to study disease as the cumulative deleterious function of a collection of individual genes and networks of molecules acting in concert. These "human disease networks" (HDN) have revealed novel candidate genes and pharmaceutical targets for many diseases and identified fundamental HDN features conserved across diseases. A network-based analysis is particularly vital for a study on polygenic diseases where many interactions between molecules should be simultaneously examined and elucidated. We employ a new knowledge driven HDN gene and molecular database systems approach to analyze Inflammatory Bowel Disease (IBD), whose pathogenesi

SUBMITTER: Suzuki S 

PROVIDER: S-EPMC3368714 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature