Genetic variations in APPL2 are associated with overweight and obesity in a Chinese population with normal glucose tolerance.

ABSTRACT:

Background

APPL1 and APPL2 are two adaptor proteins, which can mediate adiponectin signaling via binding to N terminus of adiponectin receptors in muscle cells. Genes encoding adiponectin and adiponectin receptors contribute to insulin resistance and the risk of obesity, and genetic variants of APPL1 are associated with body fat distribution. However, the association between genetic variations of APPL2 and metabolic traits remains unknown. In the current study, we aimed to test the impacts of APPL2 genetic variants on obesity in a Chinese population with normal glucose tolerance.

Methods

We genotyped six single nucleotide polymorphisms (SNPs) in APPL2 in 1,808 non-diabetic subjects. Overweight and obesity were defined by body mass index (BMI). Obesity-related anthropometric

SUBMITTER: Jiang S 

PROVIDER: S-EPMC3368742 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature