Lack of genomic imprinting of DNA primase, polypeptide 2 (PRIM2) in human term placenta and white blood cells.
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ABSTRACT:
SUBMITTER: Chung J
PROVIDER: S-EPMC3368808 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
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Lack of genomic imprinting of DNA primase, polypeptide 2 (PRIM2) in human term placenta and white blood cells.
Chung Jaewook J Tsai Shengdar S James Andra H AH Thames Betty H BH Shytle Stephanie S Piedrahita Jorge A JA
Epigenetics 20120501 5
PRIM2, encoding a subunit of primase involved in DNA replication and transcription, is expressed in the placenta and is crucial for mammalian development and growth. Its role in placental function is not well understood. Recently, PRIM2 was reported as imprinted in human white blood cells (WBC). We report here our failure to confirm imprinting of the PRIM2 locus in human placenta or WBC. The discordance between our results and those of others are likely due to an incorrectly annotated PRIM2 pseu ...[more]
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