Psychoactive pharmaceuticals induce fish gene expression profiles associated with human idiopathic autism.

ABSTRACT: Idiopathic autism, caused by genetic susceptibility interacting with unknown environmental triggers, has increased dramatically in the past 25 years. Identifying environmental triggers has been difficult due to poorly understood pathophysiology and subjective definitions of autism. The use of antidepressants by pregnant women has been associated with autism. These and other unmetabolized psychoactive pharmaceuticals (UPPs) have also been found in drinking water from surface sources, providing another possible exposure route and raising questions about human health consequences. Here, we examined gene expression patterns of fathead minnows treated with a mixture of three psychoactive pharmaceuticals (fluoxetine, venlafaxine & carbamazepine) in dosages intended to be similar to the highest o

SUBMITTER: Thomas MA 

PROVIDER: S-EPMC3368908 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature