Genetic association of zinc transporter 8 (ZnT8) autoantibodies in type 1 diabetes cases.

ABSTRACT:

Aims/hypothesis

Autoantibodies to zinc transporter 8 (ZnT8A) are associated with risk of type 1 diabetes. Apart from the SLC30A8 gene itself, little is known about the genetic basis of ZnT8A. We hypothesise that other loci in addition to SLC30A8 are associated with ZnT8A.

Methods

The levels of ZnT8A were measured in 2,239 British type 1 diabetic individuals diagnosed before age 17 years, with a median duration of diabetes of 4 years. Cases were tested at over 775,000 loci genome wide (including 53 type 1 diabetes associated regions) for association with positivity for ZnT8A. ZnT8A were also measured in an independent dataset of 855 family members with type 1 diabetes.

Results

Only FCRL3 on chromosome 1q23.1 and the HLA class I region were associated with positivity fo

SUBMITTER: Howson JM 

PROVIDER: S-EPMC3369141 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature