Inhibition of HDAC9 increases T regulatory cell function and prevents colitis in mice.

ABSTRACT:

Background & aims

Foxp3+ T regulatory cells (Tregs) help prevent autoimmunity, and increases in their numbers of functions could decrease the development of inflammatory bowel disease. Like other cells, Foxp3+ Tregs express histone/protein deacetylases (HDACs), which regulate chromatin remodeling and gene expression. We investigated whether disruption of a specific class IIa HDAC, HDAC9, activity in Tregs affects the pathogenesis of colitis in mice.

Methods

We tested the effects of various HDAC inhibitors (HDACi) in models of colitis using wild-type mice. We also transferred Tregs and non-Treg cells from HDAC9-/- or wild-type mice to immunodeficient mice. HDAC9 contributions to the functions of Tregs were determined during development and progression of colitis.

Results</

SUBMITTER: de Zoeten EF 

PROVIDER: S-EPMC3369426 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature