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Treatment response and long term follow-up results of nonspecific interstitial pneumonia.


ABSTRACT: The purpose of this study was to investigate the long-term clinical course of non-specific interstitial pneumonia (NSIP) and to determine which factors are associated with a response to steroid therapy and relapse. Thirty-five patients with pathologically proven NSIP were included. Clinical, radiological, and laboratory data were reviewed retrospectively. The male-to-female ratio was 7:28 (median age, 52 yr). Thirty (86%) patients responded to steroid therapy, and the median follow-up was 55.2 months (range, 15.9-102.0 months). Five patients (14%) showed sustained disease progression and three died despite treatment. In the five with sustained disease progression, NSIP was associated with various systemic conditions, and the seropositivity of fluorescent antinuclear antibody was significantly associated with a poor response to steroids (P = 0.028). The rate of relapse was 25%, but all relapsed patients improved after re-treatment. The initial dose of steroids was significantly low in the relapse group (P = 0.020). In conclusion, progression is associated with various systemic conditions in patients who show progression. A low dose of initial steroids is significantly associated with relapse.

SUBMITTER: Lee JY 

PROVIDER: S-EPMC3369453 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature

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Treatment response and long term follow-up results of nonspecific interstitial pneumonia.

Lee Ji Yeon JY   Jin Sang-Man SM   Lee Byoung Jun BJ   Chung Doo Hyun DH   Jang Bo-Gun BG   Park Heae Surng HS   Lee Sang-Min SM   Yim Jae-Joon JJ   Yang Seok-Chul SC   Yoo Chul-Gyu CG   Han Sung Koo SK   Shim Young-Soo YS   Kim Young Whan YW  

Journal of Korean medical science 20120526 6


The purpose of this study was to investigate the long-term clinical course of non-specific interstitial pneumonia (NSIP) and to determine which factors are associated with a response to steroid therapy and relapse. Thirty-five patients with pathologically proven NSIP were included. Clinical, radiological, and laboratory data were reviewed retrospectively. The male-to-female ratio was 7:28 (median age, 52 yr). Thirty (86%) patients responded to steroid therapy, and the median follow-up was 55.2 m  ...[more]

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