Subthalamic deep brain stimulation at individualized frequencies for Parkinson disease.

ABSTRACT:

Objectives

The oscillation model of Parkinson disease (PD) states that, in the subthalamic nucleus (STN), increased θ (4-10 Hz) and β (11-30 Hz) frequencies were associated with worsening whereas γ frequencies (31-100 Hz) were associated with improvement of motor symptoms. However, the peak STN frequency in each band varied widely from subject to subject. We hypothesized that STN deep brain stimulation (DBS) at individualized γ frequencies would improve whereas θ or β frequencies would worsen PD motor signs.

Methods

We prospectively studied 13 patients with PD. STN local field potential (LFP) was recorded after electrode implantations, in the OFF and then in ON dopaminergic medication states while patients performed wrist movements. Six individual peak frequencies of the STN

SUBMITTER: Tsang EW 

PROVIDER: S-EPMC3369506 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature