Risk of fractures in patients with multiple sclerosis: a population-based cohort study.

ABSTRACT:

Objective

To examine the risk of fracture in patients with multiple sclerosis (MS) compared with population-based controls.

Methods

A population-based cohort study was performed in the Dutch PHARMO Record Linkage System (1998-2008). Patients with MS (n = 2,415) were matched by year of birth, sex, and practice to up to 6 patients without MS (controls). We used Cox proportional hazards models to estimate the hazard ratio (HR) of fracture in MS. Time-dependent adjustments were made for age, history of disease, and drug use.

Results

During follow-up, there were 59 fractures among patients with MS (2.4%) and 227 fractures among controls (1.8%). Patients with MS had a 1.7-fold increased risk of osteoporotic fracture (HR 1.73 [95% confidence interval (CI) 1.18-2.53]) and a 4

SUBMITTER: Bazelier MT 

PROVIDER: S-EPMC3369507 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature