Multicenter validation of a bedside antisaccade task as a measure of executive function.

ABSTRACT:

Objective

To create and validate a simple, standardized version of the antisaccade (AS) task that requires no specialized equipment for use as a measure of executive function in multicenter clinical studies.

Methods

The bedside AS (BAS) task consisted of 40 pseudorandomized AS trials presented on a laptop computer. BAS performance was compared with AS performance measured using an infrared eye tracker in normal elders (NE) and individuals with mild cognitive impairment (MCI) or dementia (n = 33). The neuropsychological domain specificity of the BAS was then determined in a cohort of NE, MCI, and dementia (n = 103) at UCSF, and the BAS was validated as a measure of executive function in a 6-center cohort (n = 397) of normal adults and patients with a variety of brain diseases

SUBMITTER: Hellmuth J 

PROVIDER: S-EPMC3369520 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature