Long-term soy isoflavone supplementation and cognition in women: a randomized, controlled trial.

ABSTRACT:

Objective

To determine the cognitive effects of long-term dietary soy isoflavones in a daily dose comparable to that of traditional Asian diets.

Methods

In the double-blind Women's Isoflavone Soy Health trial, healthy postmenopausal women were randomly allocated to receive daily 25 g of isoflavone-rich soy protein (91 mg of aglycone weight of isoflavones: 52 mg of genistein, 36 mg of daidzein, and 3 mg glycitein) or milk protein-matched placebo. The primary cognitive endpoint compared between groups at 2.5 years was change from baseline on global cognition, a composite of the weighted sum of 14 neuropsychological test score changes. Secondary outcomes compared changes in cognitive factors and individual tests.

Results

A total of 350 healthy postmenopausal women aged 4

SUBMITTER: Henderson VW 

PROVIDER: S-EPMC3369523 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature