The Diesel Exhaust in Miners study: a nested case-control study of lung cancer and diesel exhaust.

ABSTRACT:

Background

Most studies of the association between diesel exhaust exposure and lung cancer suggest a modest, but consistent, increased risk. However, to our knowledge, no study to date has had quantitative data on historical diesel exposure coupled with adequate sample size to evaluate the exposure-response relationship between diesel exhaust and lung cancer. Our purpose was to evaluate the relationship between quantitative estimates of exposure to diesel exhaust and lung cancer mortality after adjustment for smoking and other potential confounders.

Methods

We conducted a nested case-control study in a cohort of 12 315 workers in eight non-metal mining facilities, which included 198 lung cancer deaths and 562 incidence density-sampled control subjects. For each case subject,

SUBMITTER: Silverman DT 

PROVIDER: S-EPMC3369553 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature