Spry1 as a novel regulator of erythropoiesis, EPO/EPOR target, and suppressor of JAK2.

ABSTRACT: Sprouty proteins are established modifiers of receptor tyrosine kinase (RTK) signaling and play important roles in vasculogenesis, bone morphogenesis, and renal uteric branching. Little is understood, however, concerning possible roles for these molecular adaptors during hematopoiesis. Within erythroid lineage, Spry1 was observed to be selectively and highly expressed at CFU-e to erythroblast stages. In analyses of possible functional roles, an Mx1-Cre approach was applied to conditionally delete Spry1. At steady state, Spry1 deletion selectively perturbed erythroid development and led to reticulocytosis plus heightened splenic erythropoiesis. When challenged by hemolysis, Spry1-null mice exhibited worsened anemia and delayed recovery. During short-term marrow transplantation, Spry1-null d

SUBMITTER: Sathyanarayana P 

PROVIDER: S-EPMC3369686 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature