Abnormal structural and functional brain connectivity in gray matter heterotopia.

ABSTRACT:

Purpose

Periventricular nodular heterotopia (PNH) is a malformation of cortical development associated with epilepsy and dyslexia. Evidence suggests that heterotopic gray matter can be functional in brain malformations and that connectivity abnormalities may be important in these disorders. We hypothesized that nodular heterotopia develop abnormal connections and systematically investigated the structural and functional connectivity of heterotopia in patients with PNH.

Methods

Eleven patients were studied using diffusion tensor tractography and resting-state functional connectivity MRI with bold oxygenation level-dependent (BOLD) imaging. Fiber tracks with a terminus within heterotopic nodules were visualized to determine structural connectivity, and brain regions demonstrat

SUBMITTER: Christodoulou JA 

PROVIDER: S-EPMC3370071 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature