Behavioral actions of alcohol: phenotypic relations from multivariate analysis of mutant mouse data.

ABSTRACT: Behavioral studies on genetically diverse mice have proven powerful for determining relationships between phenotypes and have been widely used in alcohol research. Most of these studies rely on naturally occurring genetic polymorphisms among inbred strains and selected lines. Another approach is to introduce variation by engineering single-gene mutations in mice. We have tested 37 different mutant mice and their wild-type controls for a variety (31) of behaviors and have mined this data set by K-means clustering and analysis of correlations. We found a correlation between a stress-related response (activity in a novel environment) and alcohol consumption and preference for saccharin. We confirmed several relationships detected in earlier genetic studies, including positive correlation of a

SUBMITTER: Blednov YA 

PROVIDER: S-EPMC3370096 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature