Genetic associations of surfactant protein D and angiotensin-converting enzyme with lung disease in preterm neonates.

ABSTRACT:

Objective

To replicate genetic associations with respiratory distress syndrome (RDS) and bronchopulmonary dysplasia (BPD) in genes related to surfactant deficiency, inflammation and infection, and the renin-angiotensin system.

Study design

We examined eight candidate genes for associations with RDS and BPD in 433 preterm birth (PTB-<37 weeks) infants (251 with RDS and 134 with BPD). Both case-control and family-based analyses were performed in preterm (<37 weeks) and very preterm birth (VPTB-<32 weeks) infants.

Result

We replicated a previous finding that rs1923537, a marker downstream of surfactant protein D (SFTPD) is associated with RDS in VPTB infants in that the T allele was overtransmitted from parents to offspring with RDS (P=8.4 × 10(-3)). We also observed the

SUBMITTER: Ryckman KK 

PROVIDER: S-EPMC3370386 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature