Reduction of ischemia and reperfusion-induced myocardial damage by cytochrome P450 inhibitors.

ABSTRACT: Ischemia and reperfusion both contribute to tissue damage after myocardial infarction. Although many drugs have been shown to reduce infarct size when administered before ischemia, few have been shown to be effective when administered at reperfusion. Moreover, although it is generally accepted that a burst of reactive oxygen species (ROS) occurs at the onset of reperfusion and contributes to tissue damage, the source of ROS and the mechanism of injury is unclear. We now report the finding that chloramphenicol administered at reperfusion reduced infarct size by 60% in a Langendorff isolated perfused rat heart model, and that ROS production was also substantially reduced. Chloramphenicol is an inhibitor of mitochondrial protein synthesis and is also an inhibitor of a subset of cytochrome P45

SUBMITTER: Granville DJ 

PROVIDER: S-EPMC337051 | biostudies-literature | 2004 Feb

REPOSITORIES: biostudies-literature