Persistently active cannabinoid receptors mute a subpopulation of hippocampal interneurons.

ABSTRACT: Cortical information processing requires an orchestrated interaction between a large number of pyramidal cells and albeit fewer, but highly diverse GABAergic interneurons (INs). The diversity of INs is thought to reflect functional and structural specializations evolved to control distinct network operations. Consequently, specific cortical functions may be selectively modified by altering the input-output relationship of unique IN populations. Here, we report that persistently active cannabinoid receptors, the site of action of endocannabinoids, and the psychostimulants marijuana and hashish, switch off the output (mute) of a unique class of hippocampal INs. In paired recordings between cholecystokinin-immunopositive, mossy fiber-associated INs, and their target CA3 pyramidal cells, no po

SUBMITTER: Losonczy A 

PROVIDER: S-EPMC337058 | biostudies-literature | 2004 Feb

REPOSITORIES: biostudies-literature