Division of labor among distinct subtypes of inhibitory neurons in a cortical microcircuit of working memory.

ABSTRACT: A conspicuous feature of cortical organization is the wide diversity of inhibitory interneurons; their differential computational functions remain unclear. Here we propose a local cortical circuit in which three major subtypes of interneurons play distinct roles. In a model designed for spatial working memory, stimulus tuning of persistent activity arises from the concerted action of widespread inhibition mediated by perisoma-targeting (parvalbumin-containing) interneurons and localized disinhibition of pyramidal cells via interneuron-targeting (calretinin-containing) interneurons. Moreover, resistance against distracting stimuli (a fundamental property of working memory) is dynamically controlled by dendrite-targeting (calbindin-containing) interneurons. The experimental observation of in

SUBMITTER: Wang XJ 

PROVIDER: S-EPMC337059 | biostudies-literature | 2004 Feb

REPOSITORIES: biostudies-literature