Analysis of the CtrA pathway in Magnetospirillum reveals an ancestral role in motility in alphaproteobacteria.

ABSTRACT: Developmental events across the prokaryotic life cycle are highly regulated at the transcriptional and posttranslational levels. Key elements of a few regulatory networks are conserved among phylogenetic groups of bacteria, although the features controlled by these conserved systems are as diverse as the organisms encoding them. In this work, we probed the role of the CtrA regulatory network, conserved throughout the Alphaproteobacteria, in the magnetotactic bacterium Magnetospirillum magneticum strain AMB-1, which possesses unique intracellular organization and compartmentalization. While we have shown that CtrA in AMB-1 is not essential for viability, it is required for motility, and its putative phosphorylation state dictates the ability of CtrA to activate the flagellar biosynthesis ge

SUBMITTER: Greene SE 

PROVIDER: S-EPMC3370617 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature