An efficient synthesis of the 4'-epimer of 2-fluoronoraristeromycin.

ABSTRACT: The 4'-epimer of 2-fluoronoraristeromycin was synthesized by employing bis-t-butoxycarbonyl (Boc) protected 2-fluoroadenine as a superior substrate for the Mitsunobu reaction with the appropriate cyclopentenol. Unlike the unsubstituted counterpart 2-fluoroadenine, this substrate is completely soluble in THF and resulted in a very good yield in the Mitsunobu coupling reaction as well as subsequent steps.

SUBMITTER: Bazile Q 

PROVIDER: S-EPMC3370682 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature