Antiangiogenic activity of rPAI-1(23) promotes vasa vasorum regression in hypercholesterolemic mice through a plasmin-dependent mechanism.

ABSTRACT:

Rationale

The antiangiogenic activity of rPAI-1(23), a truncated plasminogen activator inhibitor-1 (PAI-1) protein, induces vasa vasorum collapse and significantly reduces plaque area and plaque cholesterol in hypercholesterolemic low-density lipoprotein receptor-deficient/apolipoprotein B48-deficient mice.

Objective

The objective of this study was to examine rPAI-1(23)-stimulated mechanisms that cause vasa vasorum collapse.

Methods and results

The rPAI-1(23) protein opposed PAI-1 antiproteolytic function by stimulating a 1.6-fold increase in plasmin activity compared with the saline-treated counterpart. The increased proteolytic activity corresponded to increased activity of matrix metalloproteinase-3 and degradation of fibrin(ogen), nidogen, and perlecan in the adve

SUBMITTER: Mollmark J 

PROVIDER: S-EPMC3370683 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature